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RAS Chemistry & Material ScienceЖурнал аналитической химии Journal of Analytical Chemistry

  • ISSN (Print) 0044-4502
  • ISSN (Online) 3034-512X

DETERMINATION OF DOXORUBICIN BASED ON QUENCHING OF LUMINESCENCE OF ALLOYED QUANTUM DOTS

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PII
S3034512X25120048-1
DOI
10.7868/S3034512X25120048
Publication type
Article
Status
Published
Authors
D.G. Koganova
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
D.V. Tsyupka
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
D.D. Drozd
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
S.A. Mescheriakova
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
P.S. Pidenko
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
D.A. Kornilov
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
O.A. Goryacheva
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
I.Yu. Goryacheva
  • Affiliation: Saratov State University named after N. G. Chernyshevsky
Volume/ Edition
Volume 80 / Issue number 12
Pages
1319-1330
Abstract
A sensitive, simple method for determining doxorubicin (Dox) in biological fluids, which does not require complex sample preparation, has been developed based on the quenching of luminescence of thioglycolic acid-stabilized CdZnSeS/ZnS quantum dots (QDs). Luminescence quenching was studied in model solutions and human blood plasma to establish optimal determination parameters. Optimal conditions for Dox detection were selected: QDs with optical density A = 0.05 and 25-fold plasma dilution. The developed method was applied to analyze a human blood sample. The limit of detection for Dox was 0.02 µg/mL, the limit of quantification 0.18 µg/mL, the linear range 0.27–4.07 µg/mL (R > 0.96); the method showed good reproducibility (s from 1.08 to 1.19%). The method's accuracy was confirmed by HPLC with UV detection.
Keywords
доксорубицин квантовые точки тушение люминесценции клинические анализы
Date of publication
06.02.2026
Year of publication
2026
Number of purchasers
0
Views
92

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