- PII
- 10.31857/S0044450224050057-1
- DOI
- 10.31857/S0044450224050057
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 79 / Issue number 5
- Pages
- 470-478
- Abstract
- Substitution reactions in carbocyanine dyes are used to determine nucleophilic compounds. The interaction of a chlorine-containing carbocyanine with a number of medicinal substances has been studied. It was shown that in the reaction with isoniazid in the presence of surfactants, this dye selectively changes color from yellow-green to purple. Chromatography-mass spectrometry has proven the formation of the substitution product of chlorine with isoniazid. The reaction occurs within 20 minutes in the presence of 1 mM cetyltrimethylammonium bromide. The detection limit of isoniazid in water by photometric method was 10 µg/mL; in diluted artificial urine using fluorimetry, it was 0.3 µg/mL. The method does not require full-spectrum equipment, which simplifies the determination.
- Keywords
- изониазид фотометрия флуориметрия карбоцианиновый краситель
- Date of publication
- 14.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 14
References
- 1. Liu Y., Yu Y., Zhao Q., Tang C., Zhang H., Qin Y., Feng X., Zhang J. Fluorescent probes based on nucleophilic aromatic substitution reactions for reactive sulfur and selenium species: Recent progress, applications, and design strategies // Coord. Chem. Rev. 2021. V. 427. Article 213601.
- 2. Gopika G.S., Prasad P.H., Lekshmi A.G., Lekshmypriya S., Sreesaila S., Arunima C., Malavika S.K., Anil A., Sreekumar A., Pillai Z.S. Chemistry of cyanine dyes // Mater. Today Proc. 2021. V. 46. P. 3102.
- 3. Gorka A.P., Nani R.R., Schnermann M.J. Harnessing cyanine reactivity for optical imaging and drug delivery // Acc. Chem. Res. 2018. V. 51. P. 3226.
- 4. Ernst L.A., Gupta R.K., Mujumdar R.B., Waggoner A.S. Cyanine dye labeling reagents for sulfhydryl groups // Cytometry. 1989. V. 10. P. 3.
- 5. Wang X., Lv J., Yao X., Li Y., Huang F., Li M., Huang F., Li M., Yang J., Ruana X., Tang B. Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation // Chem. Comm. 2014. V. 50. P. 15439.
- 6. Sun Y., Fan S., Zhang S., Zhao D., Duan L., Li R. A fluorescent turn-on probe based on benzo[e]indolium for bisulfite through 1, 4-addition reaction // Sens. Actuators B. 2014. V. 193. P. 173.
- 7. Seifart H.I., Gent W.L., Parkin D.P., van Jaarsveld P.P., Donaid P.R. High-performance liquid chromatographic determination of isoniazid, acetylisoniazid and hydrazine in biological fluids // J. Chromatogr. B. 1995. V. 674. P. 269.
- 8. Bergamini M.F., Santos D.P., Zanoni M.V.B. Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-L-histidine // Bioelectrochemistry. 2010. V. 77. P. 133.
- 9. Safavi A., Karimi M.A., Hormozi Nezhad M.R., Kamali R., Saghir N. Sensitive indirect spectrophotometric determination of isoniazid // Spectrochim. Acta A. 2004. V. 60. P. 765.
- 10. Lapa R.A.S., Lima J.L.F.C., Santos J.L.M. Fluorimetric determination of isoniazid by oxidation with cerium (IV) in a multicommutated flow system // Anal. Chim. Acta. 2000. V. 419. P. 17.
- 11. Wen X.R., Tu C.Q. Spectrophotometric determination of isoniazid in pharmaceutical sample by silicomolybdenum blue // Adv. Mat. Res. 2014. V. 1033. P. 548.
- 12. Zhang H., Wu L., Li Q., Du X. Determination of isoniazid among pharmaceutical samples and the patients’ saliva samples by using potassium ferricyanide as spectroscopic probe reagent // Anal. Chim. Acta. 2008. V. 628. P. 67.
- 13. Espinosa-Mansilla A., Acedo-Valenzuela M.I., De La Peña A.M., Cañada F.C., López F.S. Determination of antitubercular drugs in urine and pharmaceuticals by LC using a gradient flow combined with programmed diode array photometric detection // Talanta. 2002. V. 58. P. 273.
- 14. Okoh O.A., Bisby R.H., Lawrence C.L., Rolph C.E., Smith R.B. Promising near-infrared non-targeted probes: Benzothiazole heptamethine cyanine dyes // J. Sulfur Chem. 2014. V. 35. P. 42.
- 15. Doroshenko I.A., Aminulla K.G., Azev V.N., Kulinich T.M., Vasilichin V.A., Shtil A.A., Podrugina T.A. Synthesis of modified conformationally fixed tricarbocyanine dyes for conjugation with therapeutic agents // Mendeleev Commun. 2021. V. 31. P. 615.
- 16. Sarigul N., Korkmaz F., Kurultak İ. A new artificial urine protocol to better imitate human urine // Sci. Rep. 2019. Т. 9. №. 1. С. 20159.
- 17. Njiojob C.N., Owens E.A., Narayana L., Hyun H., Choi H.S., Henary M. Tailored Near-Infrared Contrast Agents for Image Guided Surgery // J. Med. Chem. 2015. V. 58. P. 2845.
- 18. Евгеньев М.И., Гармонов С.Ю., Зайнутдинов Л.А., Маланичева Т.Г. Неинвазивный метод определений биохимического фенотипа ацетилирования // Казанский мед. журн. 2004. №. 5. С. 388.
- 19. Гаевая Л.В. Вопросы фармакокинетики и фармакодинамики изониазида // Клиническая инфектология и паразитология. 2015. №. 2. С. 15.
