RAS Chemistry & Material ScienceЖурнал аналитической химии Journal of Analytical Chemistry

  • ISSN (Print) 0044-4502
  • ISSN (Online) 3034-512X

NEW HYPERBRANCHED ZWITTERIONIC SORBENTS FOR HPLC AND METHODS FOR CONTROLLING THEIR SEPARATION CAPACITY

PII
S3034512X25110056-1
DOI
10.7868/S3034512X25110056
Publication type
Article
Status
Published
Authors
Volume/ Edition
Volume 80 / Issue number 11
Pages
1175-1188
Abstract
A series of sorbents based on silica gel with zwitterionic functional layers attached via a spacer based on 1,4-butanediol diglycidyl ether was synthesized. The influence of structural fragments of the stationary phase on chromatographic properties in hydrophilic interaction chromatography was studied, and the multifunctional separation capabilities for neutral polar, hydrophobic, and negatively charged compounds were demonstrated. Based on the identified patterns, a sorbent with high separation capacity for carboxylic acids was developed, enabling the separation of 13 organic acids in 25 minutes with a resolution of at least 1.0.
Keywords
гидрофильная хроматография многофункциональные неподвижные фазы цвиттер-ионы гиперразветвленные сорбенты
Date of publication
01.11.2025
Year of publication
2025
Number of purchasers
0
Views
35

References

  1. 1. Buszewski B., Noga S. Hydrophilic interaction liquid chromatography (HILIC) – A powerful separation technique // Anal. Bioanal. Chem. 2012. V. 402. P. 231. https://doi.org/10.1007/s00216-011-5308-5
  2. 2. Chester T.L. Recent developments in high-performance liquid chromatography stationary phases // Anal. Chem. 2013. V. 85. № 2. P. 579. https://doi.org/10.1021/ac303180y
  3. 3. Li S., Li Z., Zhang F., Geng H., Yang B. A polymerbased zwitterionic stationary phase for hydrophilic interaction chromatography // Talanta. 2020. V. 216. Article 120927. https://doi.org/10.1016/j.talanta.2020.120927
  4. 4. Guo H., Liu R., Yang J., Yang B., Liang X., Chu C. A novel click lysine zwitterionic stationary phase for hydrophilic interaction liquid chromatography // J. Chromatogr. A. 2012. V. 1223. P. 47. https://doi.org/10.1016/j.chroma.2011.12.033
  5. 5. Nesterenko E.P., Nesterenko P.N., Paull B. Zwitterionic ion-exchangers in ion chromatography: A review of recent developments // Anal. Chim. Acta. 2009. V. 652. P. 3. https://doi.org/10.1016/j.aca.2009.06.010
  6. 6. Jandera P., Janas P. Recent advances in stationary phases and understanding of retention in hydrophilic interaction chromatography. A review // Anal. Chim. Acta. 2017. V. 967. P. 12. https://doi.org/10.1016/j.aca.2017.01.060
  7. 7. Wang X., Zhu T., Wang X., Peng H., Zhou G., Peng J. Preparation of two zwitterionic polymer functionalized stationary phases and comparative evaluation under mixed-mode of reversed phase/ hydrophilic interaction/ion exchange chromatography // J. Chromatogr. A. 2024. V. 1714. Article 464586. https://doi.org/10.1016/j.chroma.2023.464586
  8. 8. Bo C., Wang X., Wang C., Wei Y. Preparation of hydrophilic interaction/ion-exchange mixed-mode chromatographic stationary phase with adjustable selectivity by controlling different ratios of the co-monomers // J. Chromatogr. A. 2017. V. 1487. P. 201. https://doi.org/10.1016/j.chroma.2017.01.061
  9. 9. Nesterenko P.N., Haddad P.R. Zwitterionic ion-exchangers in liquid chromatography // Anal. Sci. 2000. V. 16. P. 565. https://doi.org/10.2116/analsci.16.565
  10. 10. Peng H., Wang X., Peng J., He Y., Chen Y., Chen F., Li S. Preparation and evaluation of surface-bonded phenylglycine zwitterionic stationary phase // Anal. Bioanal. Chem. 2018. V. 410. № 23. P. 5941. https://doi.org/10.1007/s00216-018-1211-7
  11. 11. Чернобровкина А.В, Смоленков А.Д., Шпигун О.А. Гидрофильная хроматография – перспективный метод определения полярных веществ // Лаб. Про. 2018. № 4. С. 76. https://doi.org/10.32757/2619-0923.2018.4.4.76.92
  12. 12. Kawase I., Wah L.L., Takeuchi T. Investigation of chromatographic performance of hyperbranched amine-modified stationary phases in ion chromatography // Chromatography. 2017. V. 38. № 1. P. 9. https://doi.org/10.15583/jpchrom.2016.018
  13. 13. Popov A.S., Spiridonov K.A., Uzhel A.S., Smolenkov A.D., Chernobrovkina A.V., Zatirakha A.V. Prospects of using hyperbranched stationary phase based on poly(styrene-divinylbenzene) in mixed-mode chromatography // J. Chromatogr. A. 2021. V. 1642. P. 11. https://doi.org/10.1016/j.chroma.2021.462010
  14. 14. Uzhel A.S., Zatirakha A.V., Smirnov K.N., Smolenkov A.D., Shpigun O.A. Anion exchangers with negatively charged functionalities in hyperbranched ion-exchange layers for ion chromatography // J. Chromatogr. A. 2017. V. 1482. P. 56. https://doi.org/10.1016/j.chroma.2016.12.066
  15. 15. Uzhel A.S., Gorbovskaya A.V., Zatirakha A.V., Smolenkov A.D., Shpigun O.A. Manipulating selectivity of covalently-bonded hyperbranched anion exchangers toward organic acids. Part I: Influence of primary amine substituents in the internal part of the functional layer // J. Chromatogr. A. 2019. V. 1589. P. 65. https://doi.org/10.1016/j.chroma.2018.12.052
  16. 16. Uzhel A.S., Gorbovskaya A.V., Zatirakha A.V., Smolenkov A.D., Shpigun O.A. Manipulating selectivity of covalently-bonded hyperbranched anion exchangers toward organic acids. Part II: Effect of mono- and dicarboxylic amino acids in the internal part of the functional layer // J. Chromatogr. A. 2019. V. 1596. P. 117. https://doi.org/10.1016/j.chroma.2019.03.006
  17. 17. Uzhel A.S., Zatirakha A.V., Smolenkov A.D., Shpigun O.A. Quantification of inorganic anions and organic acids in apple and orange juices using novel covalently-bonded hyperbranched anion exchanger with improved selectivity // J. Chromatogr. A. 2018. V. 1567. P. 130. https://doi.org/10.1016/j.chroma.2018.06.065
  18. 18. Chikurova N.Yu., Shemiakina A.O., Shpigun O.A., Chernobrovkina A.V. Multicomponent Ugi reaction as a tool for fast and easy preparation of stationary phases for hydrophilic interaction liquid chromatography. Part I: The influence of attachment and spacing of the functional ligand obtained via the Ugi reaction // J. Chromatogr. A. 2022. V. 1666. Article 462804. https://doi.org/10.1016/j.chroma.2022.462804
  19. 19. Kawachi Y., Ikegami T., Takubo H., Ikegami Y., Miyamoto M., Tanaka N. Chromatographic characterization of hydrophilic interaction liquid chromatography stationary phases: Hydrophilicity, charge effects, structural selectivity, and separation efficiency // J. Chromatogr. A. 2011. V. 1218. № 35. P. 5903. https://doi.org/10.1016/j.chroma.2011.06.048
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